Normal Female and t h e Male Breast Epithel ium does not Express Prostate - Specific Antigen
نویسندگان
چکیده
In the normal female and male breast epithelial structures any prostate-specific antigen (PSA) immunohistochemical positivity was observed Variable PSA expression, which often borders the positivity, was observed in membranes of adipocytes of fat tissue and m the endothelium of small vessels in a female and a male breast Based on these initial observations, tissue of the normal breast, male or female, can not be considered to be the principal source of PSA
منابع مشابه
Can Prostate Specific Antigen Be Used as New Biomarker for Early Diagnosis of Breast Cancer?
Introduction: As a glycoprotein, Plasma Prostate-Specific Antigen (PSA) is mainly produced by prostate epithelial cells and is used as a major diagnostic tool for prostate cancer. A group of researchers relate the elevated number of estrogen receptors in breast cancer samples to the over-production of PSA in this type of cancer. Therefore, the present study aimed to determine the participants' ...
متن کاملProstate specific antigen staining intensity in prostatic adenocarcinoma correlates with serum prostate specific antigen , Bandar Abbas, Iran
Introduction: Prostatic adenocarcinoma is one the most common malignances and the second cause of death in males due to cancer. Prostate Specific Antigen (PZSA) serum level is the first marker to screen such patients. We aimed in this study, to assess the intensity of prostatic adenocarcinoma tissue staining with PSA staining method. Methods: In this corss-sectional study, prostatic adenocarcin...
متن کاملPRODUCTIO N OF PROSTATE-SPECIFIC ANTIGEN (PSA) BY A BREAST CANCER CELL LINE, SK-Br-3
PSA is a 33-KDa serine protease that is produced predominantly by prostate epithelium. However, it has been shown that about 30-40% of female breast tumors produce PSA and its production is associated with the presence of estrogen and progesterone receptors. We have now developed a new tissue culture system to study PSA production in breast cancer and its association with prognostic factors...
متن کاملAge Specific Reference Levels of Serum Prostate-Specific Antigen, Prostate Volume and Prostate Specific Antigen Density in Healthy Iranian Men
Background: It is relevant to highlight that there is not a precise and perfect report on either 95 percentile value (upper limit of normal range) or on appropriate reference intervals for serum PSA in Iranian population. Objective: To determine age-specific reference ranges for serum prostate-specific antigen (PSA) concentration and PSA density (PSAD) and prostate volumes in a population of he...
متن کاملCpG-PCR combined with sample pooling and mutant enrichment for CpG mutation screening in population studies.
1. Ablin RJ, Soanes WA, Bronson P, Witesby E. Precipitating antigens of the normal human prostate. J Reprod Fertil 1970;22:573–5. 2. Peehl DM. Prostate specific antigen role and function [Review]. Cancer 1995;75:2021–6. 3. Diamandis EP. New diagnostic applications and physiological functions of prostate-specific antigen [Review]. Scand J Clin Lab Invest 1995;55:105–12. 4. Graves HCB. Nonprostat...
متن کامل